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Generic name: Erythromycin Ethylsuccinate
Dosage form: Suspension, Granule for Oral Suspension; Tablet

The drug treats infection caused by certain bacteria. It also prevent attacks of rheumatic fever in particular patients. E.E.S. Granules suspension is a macrolide antibiotic. It works well to finish or slower the growth of sensitive bacteria.

Drug Description

Erythromycin is produced by a anxiety of Saccharopolyspora erythraea (formerly Streptomyces erythraeus) and belongs to the macrolide (lactone ring) group of antibiotics. It is basic and readily form of salt with acids. The base, stearate salt, and esters are poorly dispersible in water. Erythromycin Ethylsuccinate is an ester of erythromycin advisable for oral administration. Erythromycin Ethylsuccinate is chemically known as erythromycin 2'-(ethylsuccinate). Molecular formula of the drug is C43H75NO16 and molecular weight is 862.06

E.E.S. (erythromycin Ethylsuccinate) Granules are predetermined for restructuring with water. Each 5-mL teaspoonful of reconstituted cherry-flavored suspension involves Erythromycin Ethylsuccinate equal to 200 mg of erythromycin. The enjoyable tastes of fruit-flavored liquids are available for oral administration.

E.E.S. 200 Liquid (Erythromycin Ethylsuccinate): Each 5-mL teaspoonful of fruit-flavored suspension contains Erythromycin Ethylsuccinate equivalent to 200 mg of erythromycin. This liquid is supplied in 1 pint bottle and in 100-mL

E.E.S. (Erythromycin Ethylsuccinate) 400 Liquid: Each 5-mL teaspoonful of orange-flavored suspension contains Erythromycin Ethylsuccinate equivalent to 400 mg of erythromycin. This liquid is supplied in 1 pint bottle and in 100-mL

Granules and ready-made suspensions highly recommendable for pediatric use but can also be used in adults.


To reduce the advancement of drug-resistant bacteria and maintain the influences of E.E.S. and other antibacterial drugs; E.E.S. should be used strictly to treat or avert infections that are proven or strongly suspected to be caused by inclined bacteria.

E.E.S. is used in the treatment of infections caused by inclined strains of the nominated organisms in the diseases listed below:-

Streptococcus pneumonia,  Upper respiratory tract infections of mild to moderate degree caused by Streptococcus pyogenes or Haemophilus influenzae (when used collectively with adequate doses of sulfonamides, since number of strains of H. Influenzae (acute viral infection) are not inclined to the erythromycin concentrations commonly achieved).

Lower-respiratory tract infections of mild to moderate severity caused by Streptococcus pneumoniae or Streptococcus pyogenes.

Listeria monocytogenes results to Listeriosis.

Skin and skin structure infections of mild to moderate severity caused by Streptococcus pyogenes or Staphylococcus aureus (resistant staphylococci may emerge during treatment).

Respiratory tract infections are caused due to Mycoplasma pneumoniae. Some clinical studies suggest that erythromycin may be helpful in the prophylaxis of pertussis in seen susceptible individuals. Pertussis (bawling cough) caused by Bordetella pertussis. Erythromycin is effective in decreasing or curing the organism from the nasopharynx of already influenced individuals assimilating them noninfectious.

Diphtheria: Infections due to Corynebacterium diphtheriae, as an appendage to antitoxin, to conserve establishment of carriers and to eliminate the organism in carriers.

Erythrasma: In the treatment of infections caused due to Corynebacterium minutissimum.

Abdominal amebiasis caused by Entamoeba histolytica (oral erythromycins only). Extraenteric amebiasis needs treatment with other agents.

Dosage and Administration

The following dosage schedule is suggested for mild to moderate infections:



Under 10 lbs

30-50 mg/kg/day
15-25 mg/kg/q 12 h

10 to 15 lbs

200 mg

16 to 25 lbs

400 mg

26 to 50 lbs

800 mg

51 to 100 lbs

1200 mg

over 100 lbs

1600 mg



In mild to moderate infections the normal dosage of Erythromycin Ethylsuccinate for children is 30 to 50 mg/kg/day in equally divided dosage of every 6 hours for 10 to 14 days.


400 mg Erythromycin Ethylsuccinate at interval of every 6 hours is the normal dosage. Doses may also be injected thrice daily by administering one-third of the total daily dose every 8 hours. For 10 to 14 days.

For Treatment of Urethritis Due to C. trachomatis or U. urealyticum:

Dose: 800 mg three times a day for 7 days.

For Treatment of Primary Syphilis:

Adult’s dose: 48 to 64 g given in divided doses over a period of 10 to 15 days.


This medication has been prescribed based on your current condition only. Avoid consuming it later for other infections. If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and move to your usual dosing schedule. Do not double the dose to catch up.

Using Guide for the Drug:

  • Patients should be informed that this antibacterial drugs including E.E.S. (Erythromycin Ethylsuccinate) should only be used to treat bacterial infections.
  • Skipping doses or not completing the full course of therapy may decrease the capability (Erythromycin Ethylsuccinate) of the instant treatment and increasing the likelihood that bacteria will develop refusal and will not be treatable by E.E.S. (Erythromycin Ethylsuccinate) or other antibacterial drugs in the future.
  • Diarrhea is a well-known problem caused by consumption of these antibiotics which usually ends when antibiotics are discontinued. Many a times after starting treatment with antibiotics, patients can victim watery and bloody stools (with or without stomach pains and fever) even as late as two or more months after having taken the last dose of the antibiotic.

Storage of the Drug:

Different brands of this medication have different storage needed. Check the product package carefully for instructions on how to store/conserve your brand. Do not freeze or store in the bathroom (keep away from moisture). Keep all medications away from children, infants and pets. Do not flush medications down the toilet or pour them into a drain.

Side effects:

Nausea, vomiting, diarrhea, stomach pain/cramping, and loss of appetite are minor side effects. Consuming this drug with food may decrease these symptoms. If any of these effects endures or worsen, take help of other medical guidance.

Severe side effects:

This includes: signs of liver disease (such as continual nausea/vomiting, yellowing eyes or skin, dark urine, severe stomach/abdominal cramp), undefined tiredness, muscle weakness, slurred speech, blurred vision, drooping eyelids, hearing loss. Get medical help immediately if you see any serious side effects like: severe dizziness, fainting, fast/irregular heartbeats.


Some medical conditions may interact with E. E. S. drug suspension. Take a specially note of the following precautions applied to you:

  • Intake of drug should be avoided during pregnancy, during intake of any other nonprescription medicine, herbal preparation, or dietary supplement, if you are allergic to ingredient in the drug, diarrhea suffering patient
  • The drug should be avoided if patient is suffering from any kidney or liver diseases, low blood potassium or magnesium level, fast/slow or irregular heartbeats, or any blood diseases.
  • Precaution should be taken more in case of any medicine that may increase the risk of a certain type of irregular heartbeat.

Meta Description:

E. E. S. (Erythromycin Ethylsuccinate) Granules suspension is a macrolide antibiotic. It works by finishing or slowing the growth of sensitive bacteria.