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Generic Name: labetalol (la BAY ta lol)

Brand Name: Normodyne, Trandate

Forms: Intravenous solution, oral tablet, compounding powder

Labetalol is in a band of drugs which is also known as beta-blockers. Beta-blockers works by affect heart and circulation of blood flow through arteries and veins. The drug is used to work on the hypertension (high blood pressure). Nerves from the adrenergic nervous system tours from the spinal cord to arteries where they discharge norepinephrine. Norepinephrine then hooks up to adrenergic receptors on arteries by causing them to bond, contracting the arteries, and enhancing blood pressure.

Drug Description:

Trandate (labetalol) pills are adrenergic receptor arresting agents carrying both selective alpha1-adrenergic and nonselective beta-adrenergic receptor; these blocking actions with a single substance. Labetalol hydrochloride (HCl) is a racemate chemically formed as 2-hydroxy-5-[1-hydroxy-2-[(1methyl-3-phenylpropyl) amino] ethyl] benzamide monohydrochloride.

Labetalol HCl has the empirical formation can be denoted as C19H24N2O3•HCl with 364.9 as molecular weight. The drug consists of two asymmetric centers and hence exists as a molecular complex of two diastereoisomeric pairs. Dilevalol, the R,R' stereoisomer, forms up 25% of racemic labetalol. The formula is partly white or off-white crystalline type powder, which is freely soluble in water. The tablets are available in packages of 100 mg, 200mg and 300mg.

Tablet Content:

Trandate tablets encompasses 100, 200, or 300 mg of labetalol HCl. Other inactive ingredient consists of: FD&C Yellow No. 6 (100- and 300-mg tablets only), hydroxypropyl methylcellulose, lactose, magnesium stearate, pregelatinized corn starch, sodium benzoate (200-mg tablet only), talc (100-mg tablet only), and titanium dioxide.

Indications:

These tablets are pointed out in management of hypertension. Trandate (labetalol) Tablets can be consumed aloof or in combination with any other antihypertensive assistant, especially thiazide and loop diuretics.

Dosage:

Dosage must strictly individualize as per the need. The suggested initial dosage is 100 mg twice everyday which could be consumed alone or added with a diuretic regimen. The usual safe consumption of dosage is seen between 200 and 400 mg twice daily. Patients suffering from severe hypertension require 1,200 to 2,400 mg daily dosage, with or without thiazide diuretics. Titration dosage should strictly not exceed 200 mg twice daily.

Overdose:

Overdosage of medicine results in excessive hypotension, sensitive and, sometimes excessive bradycardia too. Overdose symptoms may include slow heart rate, extreme dizziness, or fainting.

Missed Dose:

Take the missed dose as soon as you remember. Skip the missed dose if your next dose is less than 8 hours away. Do not take extra medicine to make up the missed dose, as its extra consumption may prove as overdose.

Using Guide:

  • Trandate tablets are to be consumed along with food. The tablets should be swallowed as whole with plain drinking water.
  • The dosage pattern depends on the condition you are getting treated for by prescribed from your doctor. It is mandatory to follow the instructions given by doctor for healthy and positive results. Dosage, instructions, dispensing, are mentioned on label on the packet of medicine.
  • It is important that you don't suddenly stop taking this medicine unless your doctor tells you to. As sudden stoppage will cause in some adverse and severe effects or reactions.

Storage:

Trandate (labetalol) medicine should be stored between 2° and 30°C (36° and 86°F). Tablets are to be stored in the unit dose boxes protected from excessive moisture. Do not store in bathroom i.e. should be kept away from moisturized places.

Side Effects:

Some signs of an allergic reaction may be like: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Consumption of alcohol in combination of the medication can further decrease your blood pressure and may increase certain side effects. Less serious or common side effects may include: tingly feeling in your scalp; dizziness, spinning sensation; mild nausea, upset stomach; tired feeling; stuffy nose; or difficulty having an orgasm.

In addition, a number of other less common adverse events have been reported:

Body as a Whole can suffer from fever.

Cardiovascular issues like: Hypotension, and rarely, syncope, bradycardia, heart block may be seen.

Central and Peripheral Nervous Systems affects may result to: Paresthesia, most frequently described as scalp tingling. In most cases, it was mild and transient and usually occurred at the beginning of treatment and gradually decrease.

Collagen Disorders may include systemic lupus erythematosus, positive antinuclear factor.

One may result in dryness of eyes which gradually decreases with increase of getting used to with medication.

Liver and Biliary System are also affected causing hepatic necrosis, hepatitis, cholestatic jaundice, elevated liver function tests.

Musculoskeletal System affected by pill causes muscle cramps, toxic myopathy.

Bronchospasm can be victim due to reactions caused by getting affected respiratory System.

Skin and Appendages issues may develop like: rashes of various types, such as generalized maculopapular, lichenoid, urticarial, bullous lichen planus, psoriaform, and facial erythema; Peyronie's disease; reversible alopecia.

Urinary System makes it difficulty in micturition, including acute urinary bladder retention.

Hypersensitivity includes rare reports of hypersensitivity (e.g., rash, urticaria, pruritus, angioedema, dyspnea) and anaphylactoid reactions.

Precautions:

This medicine may cause fatigue and dizziness. Hence, special care should be take while performing potentially hazardous activities, like driving or operating machinery, until you know how this medicine affects you and are until you are sure that you can perform such activities safely. One should not restrict from taking this medicine all of sudden. Gradual stopping of the treatment is suggested, usually over one to two weeks, following the instructions given by your doctor for safety reasons.

The medication is only part of a complete program of treatment for hypertension which may also include diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely along with the medicinal treatment for hypertension.

Contraindications:

The tablets are contraindicated in bronchial asthma, overt cardiac collation, more-than-first-degree heart block, cardiogenic shock, severe bradycardia, with other conditions combined with severe and prolonged hypotension, and in patients with a history of hypersensitivity to any component of the product. Beta-blockers, even those with apparent cardioselectivity, should not be used in patients with a history of obstructive airway disease, including asthma.