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Generic Name: Warfarin (WAR far in)

Brand Names: Coumadin, Jantoven

Warfarin is an anticoagulant is also known as blood thinner. The solution works by reducing the blood clots. Warfarin is majorly used to reduce or rescue heart attacks, strokes, and blood clots in veins and arteries. Coumadin (warfarin sodium) is a prescribed medication used to treat blood clots and to reduce chances of blood clots assembling in body. Blood clots can lead to stroke, heart attack, or other serious conditions if they are formed in the legs or lungs. The medication may be prescribed to work on your:

  • It helps in reducing risk of constructing blood clots if you are suffering from heart-valve restoration or an irregular, rapid heartbeat, called atrial fibrillation (quality of being made up fibrils).
  • It lowers the danger of death if your history includes any event like heart attack, as well as it lowers danger of pertaining another heart attack, stroke, and having blood clots from moving to another parts of your body.

Drug Description:

Coumadin (warfarin sodium) is an anticoagulant which acts by curbing vitamin K-dependent clotting aspects. Chemically the drug can be denoted as 3-(α-acetonylbenzyl)-4- hydroxycoumarin and is a racemic mixture of the R- and S-enantiomers. Its empirical formula is C19H15NaO4,

The tablets for oral use also contain:

All strengths

Lactose, starch, and magnesium stearate

1 mg

D&C Red No. 6 Barium Lake

2 mg

FD&C Blue No. 2 Aluminum Lake and FD&C Red No. 40 Aluminum Lake

2-1/2 mg

D&C Yellow No. 10 Aluminum Lake and FD&C Blue No. 1 Aluminum Lake

3 mg

FD&C Yellow No. 6 Aluminum Lake, FD&C Blue No. 2 Aluminum Lake, and FD&C Red No. 40 Aluminum Lake

4 mg

FD&C Blue No. 1 Aluminum Lake

5 mg

FD&C Yellow No. 6 Aluminum Lake

6 mg

FD&C Yellow No. 6 Aluminum Lake and FD&C Blue No. 1 Aluminum Lake

7-1/2 mg

D&C Yellow No. 10 Aluminum Lake and FD&C Yellow No. 6 Aluminum Lake

10 mg:  Dye-free

The chemical used for injection intravenously use is available as a sterile, lyophilized powder, which, after restructuring with 2.7 mL Sterile Water for Injection, contains:

Warfarin sodium

2 mg per mL

Sodium phosphate, dibasic, heptahydrate

4.98 mg per mL

Sodium phosphate, monobasic, monohydrate

0.194 mg per mL

Sodium chloride

0.1 mg per mL

Mannitol

38.0 mg per mL

Indications:

The drug is used to help prevention and reduce blood clots in the legs, lungs, and those clots associated with heart-valve replacement or an irregular, rapid heartbeat called atrial fibrillation. If you had any history relating to heart attack, the tablet may be used to lower the risk of death, another heart attack, stroke, and blood clots transferring to other parts of the body. It is not known whether these pills are safe and effective for children.

Dosage:

The dosage and administration of the drug is to be individualized for each patient according to the patient's INR response to the drug. Adjust the dosage pattern based on the patient's INR and the condition being treated with this medication. Examine the latest evidence-based analytical method guidelines from the American College of Chest Physicians (ACCP) to assist in the assurance of the duration and anxiety of anticoagulation.

Over Dosage:

Over dosage of the drug may cause bleeding like, appearance of blood in stools or urine, hematuria, excessive menstrual bleeding, melena, petechiae, excessive bruising or persistent oozing from superficial injuries, unexplained fall in hemoglobin is a demonstration of enormous anticoagulation.

Missed Dose:

The anticoagulant effect of tablet persists endures beyond 24 hours. If a patient misses a dose at the calculated time of day, the patient should take the dose as soon as possible on the same day. The patient should not double or take dosage twice a day to make up for a missed dose.

Using Guide:

Your healthcare provider will adjust your dose from time to time depending on your response to the drug. You must have regular blood tests and visits to doctor should be time to time while getting treated with this Warfarin Sodium (Coumadin) drug.

Storage:

Tablets are preferably stored and protected from light and moisture. The tablets Warfarin Sodium (Coumadin) are suggested to be stored at room temperature (59°-86°F, 15°-30°C). Dispense in a tight, light-resistant container.

Injection: after reconstitution, store the drug at controlled room temperature (59°-86°F, 15°-30°C) and use within 4 hours. Do not refrigerate the drug. Discard any unused solution using proper disposal method. Protect the solution form light. Keep vial in box until used as you had got with the same package.

Side Effects:

Connsult a doctor as soon as possible in case you victim any of the following signs or symptoms of bleeding: pain, swelling, or discomfort, headaches, dizziness, or weakness, unusual bruising (bruises that develop without known cause or grow in size), nosebleeds or bleeding gums, bleeding from cuts takes a long time to stop, menstrual bleeding or vaginal bleeding that is heavier than normal, pink or brown urine; red or black stools, coughing up or vomiting blood; or vomiting material that looks like coffee grounds.

Serious Side Effects post consuming Warfarin Sodium (Coumadin)includes: Death of skin tissue which is also known as skin necrosis or gangrene. This can happen soon as the treatment with this chemical is started. This act happens because blood clots form and block blood flow to an area of your body.

Purple toes syndrome is caused. Like if you are suffering from having pain in your toes and they look purple or dark in color.

Precautions:

The danger of bleeding may be raised in hemodialysis patients taking the treatment. The benefit of therapy should be fully appraised before treating such patients. Safety and capabilities have not been entrenched in pediatric patients who are less than 18 years of age. However, the drug has been used in pediatric patients for restraining and analyses. It should be noted that because of difficulty consuming and maintaining therapeutic ranges in pediatric patients, more frequent monitoring had been suggested for such patient.